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SER-CAT Outstanding Science Award - 2021

Alternate: Mol Cell. 2020 Jun 18;78(6):1152-1165.e8.

Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.

The 2021 SER-CAT Outstanding Science Award will be presented to Dr. R. Scott Williams, of the National Institute of Environmental Health Sciences, Durham, NC, USA, for his outstanding work entitled: Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.

Award will be presented by: SER-CAT Director Professor Bi-Cheng Wang.

Abstract: Outstanding Science Award (2021)

Outstanding Science Awards, Previous Years

SER-CAT Young Investigator Award - 2021

Alternate: Proc Natl Acad Sci USA. 2020 Jul 14;117(28):16333-16338.doi: 10.1073/pnas.2004170117.

Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.

The 2021 SER-CAT Young Investigator Award will be presented to Ha An Nguyen, of Emory University School of Medicine, Atlanta, GA, USA, for her outstanding work entitled: Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.

Award will be presented by: SER-CAT Director Professor Bi-Cheng Wang.

Abstract: Young Investigator Award (2021)

Young Investigator Awards, Previous Years

User Science Highlight

J Am Chem Soc. 2021 Jun 2;143(21):8056-8068.

Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product.

Among the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products, "graspetides" (formerly known as microviridins) contain macrocyclic esters and amides that are formed by ATP-grasp ligase tailoring enzymes using the side chains of Asp/Glu as acceptors and Thr/Ser/Lys as donors. Graspetides exhibit diverse patterns of macrocylization and connectivities exemplified by microviridins, that have a caged tricyclic core, and thuringin and plesiocin that feature a "hairpin topology" with cross-strand ω-ester bonds...

Abstract: This User Science Highlight

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User Science Highlight

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.

Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)-variant surface antigens that are expressed on infected erythrocytes bind to the inhibitory receptor LAIR1, and insertion of DNA that encodes LAIR1 into immunoglobulin genes generates RIFIN-specific antibodies. Here we address the general relevance of this finding by searching for antibodies that incorporate LILRB1, another inhibitory receptor that binds to β2 microglobulin and RIFINs through their apical domains...

Abstract: This User Science Highlight

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User Science Highlight

Nat Commun. 2021 Jan 20;12(1):482.

High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.

DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates. Whether intrinsic ligation fidelity contributes to the accuracy of replication of the nuclear genome is unknown. Here, we show that an engineered low-fidelity LIG1Cdc9 variant confers a novel mutator phenotype...

Abstract: This User Science Highlight

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ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4

ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4.

Macrodomains are proteins that recognize and hydrolyze ADP ribose (ADPR) modifications of intracellular proteins. Macrodomains are implicated in viral genome replication and interference with host cell immune responses. They are important to the infectious cycle of Coronaviridae and Togaviridae viruses. We describe crystal structures of the conserved macrodomain from the bat coronavirus (CoV) HKU4 in complex with ligands. The structures reveal a binding cavity that accommodates ADPR...

Abstract: This User Science Highlight

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18th Annual SER-CAT Symposium; 2021

The 18th Annual SER-CAT Symposium was held March 18-19th 2021, and was hosted by the St. Jude Children's Research Hospital, of Memphis TN. The meeting was a two day St. Jude/SER-CAT Structural Biology Symposium, placing emphasis upon:

  • Remote use of SER-CAT beamlines
  • Use of Partner ALS beamlines during the APS Dark Period
  • Invited speakers, whose major contributions to biology and human disease research are propelled by X-ray Crystallography
  • Posters and pre-recorded talks

The St. Jude – SER–CAT Structural Biology Symposium website remains live; full agenda is available on website.

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