SER-CAT banner

SER‐CAT

The SouthEast Regional Collaborative Access Team (SER‐CAT) is an organization consisting of 19 Member and 4 Associate User institutions, most of which are located in the SouthEastern region of the USA.
SER‐CAT's beamlines are located at Sector 22, Advanced Photon Source (APS), Argonne National Laboratory (ANL). As a part of the APS Upgrade, they are presently being converted to two state‐of‐the‐art Insertion Device beamlines (22‐ID‐D, variable wavelength; and the new 22‐ID‐E, fixed wavelength).
Future emphasis will be placed on de novo SAD/MAD structure determination, high‐resolution structural analyses, micro crystals, large unit cells, drug design, soft X‐ray data collection, full hands‐free automated data collection, and serial synchrotron crystallography.
SER‐CAT is operated by the University of Georgia; Professor Bi‐Cheng Wang, Director.

SER-CAT Outstanding Science Award ‐ 2022

Alternate: Mol Cell. 2020 Jun 18;78(6):1152-1165.e8.

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.

The 2022 SER-CAT Outstanding Science Award was presented to Dr. Brian M. Baker, of the Harper Cancer Research Institute, University of Notre Dame, South Bend, IN, USA, for his outstanding work entitled: Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.

Award was presented by: SER-CAT Director Professor Bi-Cheng Wang.

Abstract: Outstanding Science Award (2022)

Outstanding Science Awards, Previous Years

SER-CAT Young Investigator Award ‐ 2022

doi: https://doi.org/10.1101/2021.03.04.434028.

Molecular mechanism regulating transcriptional control of the hig toxin‐antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris.

The 2022 SER-CAT Young Investigator Award was presented to Dr. Ian Pavelich, of Emory University School of Medicine, Atlanta, GA, USA, for his outstanding work entitled: Molecular mechanism regulating transcriptional control of the hig toxin-antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris.

Award was presented by: SER-CAT Director Professor Bi-Cheng Wang.

Abstract: Young Investigator Award (2022)

Young Investigator Awards, Previous Years

User Science Highlight

Commun Biol. 2023 Apr 17;6(1):423.

Structure of anhydrotetracycline‐bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.

Inactivation of tetracycline antibiotics by tetracycline destructases (TDases) remains a clinical and agricultural threat. TDases can be classified as type 1 Tet(X)-like TDases and type 2 soil-derived TDases. Type 1 TDases are widely identified in clinical pathogens. A combination therapy of tetracycline and a TDase inhibitor is much needed to rescue the clinical efficacy of tetracyclines. Anhydrotetracycline is a pan-TDase inhibitor that inhibits both type 1 and type 2 TDases...

Abstract: This User Science Highlight

Previous User Science Highlights

User Science Highlight

Nat Commun. 2023 Jan 26;14(1):433

Regions of hepatitis C virus E2 required for membrane association.

Hepatitis C virus (HCV) uses a hybrid entry mechanism. Current structural data suggest that upon exposure to low pH and Cluster of Differentiation 81 (CD81), the amino terminus of envelope glycoprotein E2 becomes ordered and releases an internal loop with two invariant aromatic residues into the host membrane. Here, we present the structure of an amino-terminally truncated E2 with the membrane binding loop in a bent conformation and the aromatic side chains sequestered...

Abstract: This User Science Highlight

Previous User Science Highlights

User Science Highlight

Nat Commun. 2022 Nov 26;13(1):7298.

Structural characterization of protective non‐neutralizing antibodies targeting Crimean‐Congo hemorrhagic fever virus.

Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a life-threatening disease with up to a 40% mortality rate. With no approved medical countermeasures, CCHFV is considered a public health priority agent. The non-neutralizing mouse monoclonal antibody (mAb) 13G8 targets CCHFV glycoprotein GP38 and protects mice from lethal CCHFV challenge when administered prophylactically or therapeutically. Here, we reveal the structures of GP38 bound with a human chimeric 13G8 mAb and a newly isolated CC5-17 mAb from a human survivor...

Abstract: This User Science Highlight

Previous User Science Highlights

User Science Highlight

Nat Commun. 2022 Nov 19;13(1):7117

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.

APOBEC3 proteins (A3s) are enzymes that catalyze the deamination of cytidine to uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral immunity. However, the APOBEC3 family has also been linked to many mutational signatures in cancer cells, which has led to an intense interest to develop inhibitors of A3's catalytic activity as therapeutics as well as tools to study A3's biochemistry, structure, and cellular function...

Abstract: This User Science Highlight

Previous User Science Highlights

19th Annual SER‐CAT Symposium; 2022

The 19th Annual SER‐CAT Virtual Symposium was held on October 20th 2022, and was hosted by the University of Georgia, of Athens, GA.

 

The UGA ‐ SER‐CAT Structural Biology Symposium website remains live; full agenda is available on website.

 

Calendar_ID

22-ID Beamline Schedule

Posted before start of run; updated throughout run.

APS Long-Range Schedule

Institutional Color Codes

Calendar_BM

22-BM Beamline Schedule

Posted before start of run; updated throughout run.

APS Long-Range Schedule

Institutional Color Codes

Calendar_Staff

SER-CAT Staff Schedule

Posted before start of run; updated throughout run.

Staff Host Color Codes

Shipping_Dewars

Looking for Beamtime?

Members, Associate Users, and GUP-Users are scheduled for beamtime using these guidelines.

Looking to become a GUP User at SER-CAT?

Franklin_College_UGA

Contact Us

Information regarding becoming a SER-CAT Member or Associate User Institution.

Laurel_Wreath_1536_960

Award Nomination Packages

Information packages, for nominating Outstanding Science or Young Investigator for SER-CAT Annual Awards.

Outstanding Science Award

Young Investigator Award

Privacy and Security Notice