Welcome and Opening Remarks:
Interesting Structures and Methods I:
Interesting Structures and Methods II:
APS and SER–CAT News:
20 Years of Light When You Need It:
Poster Session and Awards:
Registration is free, but all attendees must register to receive access. To register, please use the SER–CAT Symposium Registration website. A Full Agenda is available in this pdf.
For more information, please see the Symposium website.
POSTERS are welcome! Abstract submission instructions, for both talks and posters, available in pdf.
Symposium Contacts:
Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
The 2021 SER-CAT Outstanding Science Award was presented to Dr. R. Scott Williams, of the National Institute of Environmental Health Sciences, Durham, NC, USA, for his outstanding work entitled: Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Award was presented by: SER-CAT Director Professor Bi-Cheng Wang.
Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.
The 2021 SER-CAT Young Investigator Award was presented to Ha An Nguyen, of Emory University School of Medicine, Atlanta, GA, USA, for her outstanding work entitled: Disruption of evolutionarily correlated tRNA elements impairs accurate decoding.
Award was presented by: SER-CAT Director Professor Bi-Cheng Wang.
Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product.
Among the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products, "graspetides" (formerly known as microviridins) contain macrocyclic esters and amides that are formed by ATP-grasp ligase tailoring enzymes using the side chains of Asp/Glu as acceptors and Thr/Ser/Lys as donors. Graspetides exhibit diverse patterns of macrocylization and connectivities exemplified by microviridins, that have a caged tricyclic core, and thuringin and plesiocin that feature a "hairpin topology" with cross-strand ω-ester bonds...
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)-variant surface antigens that are expressed on infected erythrocytes bind to the inhibitory receptor LAIR1, and insertion of DNA that encodes LAIR1 into immunoglobulin genes generates RIFIN-specific antibodies. Here we address the general relevance of this finding by searching for antibodies that incorporate LILRB1, another inhibitory receptor that binds to β2 microglobulin and RIFINs through their apical domains...
High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates. Whether intrinsic ligation fidelity contributes to the accuracy of replication of the nuclear genome is unknown. Here, we show that an engineered low-fidelity LIG1Cdc9 variant confers a novel mutator phenotype...
ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4.
Macrodomains are proteins that recognize and hydrolyze ADP ribose (ADPR) modifications of intracellular proteins. Macrodomains are implicated in viral genome replication and interference with host cell immune responses. They are important to the infectious cycle of Coronaviridae and Togaviridae viruses. We describe crystal structures of the conserved macrodomain from the bat coronavirus (CoV) HKU4 in complex with ligands. The structures reveal a binding cavity that accommodates ADPR...
The 18th Annual SER-CAT Symposium was held March 18-19th 2021, and was hosted by the St. Jude Children's Research Hospital, of Memphis TN. The meeting was a two day St. Jude/SER-CAT Structural Biology Symposium, placing emphasis upon:
The St. Jude – SER–CAT Structural Biology Symposium website remains live; full agenda is available on website.
Members, Associate Users, and GUP-Users are scheduled for beamtime using these guidelines.
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Information packages, for nominating Outstanding Science or Young Investigator for SER-CAT Annual Awards.